5 Million Prescriptions

Based on total US retail prescriptions dispensed for COMBIGAN® over an aggregate 65 months ending March 2013.

HomePowerTolerabilityMOATwice-Daily DosingPatient Resources
 Twice-Daily Dosing

The recommended dose is 1 drop of COMBIGAN® in the affected eye(s) twice daily approximately 12 hours apart. If more than one topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.6

COMBIGAN® is a solution containing
2 mg/mL of brimonidine tartrate and
5 mg/mL of timolol (6.8 mg/mL of
timolol maleate).

Dosage and Administration

INDICATIONS AND USAGE: COMBIGAN® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is an alpha-adrenergic receptor agonist with a beta‐adrenergic receptor inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP; the IOP‐lowering of COMBIGAN® dosed twice a day was slightly less than that seen with the concomitant administration of 0.5% timolol maleate ophthalmic solution dosed twice a day and 0.2% brimonidine tartrate ophthalmic solution dosed three times per day.


IMPORTANT SAFETY INFORMATION
CONTRAINDICATIONS: COMBIGAN® is contraindicated in patients with bronchial asthma; a history of bronchial asthma; severe chronic obstructive pulmonary disease; in patients with sinus bradycardia; second or third degree atrioventricular block; overt cardiac failure; in neonates and infants (under the age of 2 years); in patients with a hypersensitivity reaction to any component of COMBIGAN® in the past.


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aIncludes preferred, approved, and tiers 1-4, with and without step-edits, and also includes prior authorization, based on 204,740,937 total lives.