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 Twice-Daily Dosing

The recommended dose is 1 drop of COMBIGAN® in the affected
eye(s) twice daily, approximately 12 hours apart. If more than 1 topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.7

COMBIGAN® is a solution containing 2 mg/mL of brimonidine tartrate and 5 mg/mL of timolol (6.8 mg/mL of timolol maleate).

INDICATIONS AND USAGE: COMBIGAN® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is an alpha-adrenergic receptor agonist with a beta‐adrenergic receptor inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP; the IOP‐lowering of COMBIGAN® dosed twice a day was slightly less than that seen with the concomitant administration of 0.5% timolol maleate ophthalmic solution dosed twice a day and 0.2% brimonidine tartrate ophthalmic solution dosed three times per day.

CONTRAINDICATIONS: COMBIGAN® is contraindicated in patients with reactive airway disease including bronchial asthma; a history of bronchial asthma; severe chronic obstructive pulmonary disease; in patients with sinus bradycardia; second or third degree atrioventricular block; overt cardiac failure; in neonates and infants (aged 2 years and younger); in patients with a hypersensitivity reaction to any component of COMBIGAN® in the past.

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