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 About Glaucoma - Glaucoma Treatment & Risk Factors


In patients with open-angle glaucoma, high eye pressure is a risk factor that can be treated. Medicated eyedrops are a common treatment option to reduce high eye pressure in patients with glaucoma who require additional or adjunctive IOP-lowering therapy such as COMBIGAN® ophthalmic solution. These medications are believed to decrease eye pressure by reducing the production of aqueous humor within the eye and/or increasing the drainage of it from the eye (the exact mechanism of action is not known). Laser treatment or even surgery may be needed when prescription treatment alone is insufficient.

Indication: COMBIGAN® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is approved for reducing elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP. COMBIGAN® lowers IOP slightly less than taking both brimonidine tartrate three times a day and timolol maleate two times a day.

Contraindications: COMBIGAN® ophthalmic solution should not be used by patients who have or ever had a reactive airway disease including bronchial asthma, chronic bronchitis, emphysema, slow heartbeat, impaired conduction of the heart, heart failure, or impaired pumping of the heart. COMBIGAN® should not be used in patients aged 2 years and younger, or by patients with hypersensitivity to any ingredient in this product.

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