HomeAbout GlaucomaYour TreatmentSafety InformationTalking to Your DoctorSave Now
 Your Treatment - Frequently Asked Questions
PRINT Print This Page

Frequently Asked Questions

Learn more about open-angle glaucoma, how open-angle glaucoma affects your eyes, the treatment of open-angle glaucoma, and possible risk factors.

What is COMBIGAN®?

Twice-daily COMBIGAN® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is a medication proven to effectively lower eye pressure for patients who require additional or adjunctive IOP lowering. COMBIGAN® lowers eye pressure slightly less than taking both brimonidine tartrate taken 3 times a day and timolol maleate taken 2 times a day.7


COMBIGAN® is approved to lower pressure in the eyes of people with primary open-angle glaucoma or ocular hypertension (both conditions involve high pressure in the eye).

Back to Top

Is COMBIGAN® right for me?

COMBIGAN® may be the right choice for you if you have elevated IOP and require additional or adjunctive IOP lowering.


Ask your eye care professional if COMBIGAN® ophthalmic solution may be right for you.

Back to Top

Who should NOT use COMBIGAN®?

COMBIGAN® should not be used in patients under the age of 2 years, if you are currently taking a type of antidepressant called an "MAO inhibitor," or if you have7:

  • Bronchial asthma or a history of bronchial asthma
  • Severe lung problems
  • Slow or irregular heartbeat or heart failure
  • Allergies to any of the ingredients in COMBIGAN®

COMBIGAN® eyedrops can be absorbed by your body, which may be of concern if you have other medical conditions or are taking other drugs.


It is very important to tell your eye care professional if you have7:

  • Diabetes
  • Thyroid problems
  • Liver or kidney disease
  • Depression
  • Eye injury or infection
  • Upcoming surgery for your eyes or anywhere on
    your body
  • Muscle weakness

Also tell your eye care professional about other medications you are taking, especially7:

  • Heart or blood pressure medicines, such as beta-blockers and calcium channel blockers
  • Sedatives
  • Antidepressants

These risks are not the only risks associated with COMBIGAN®. If you experience these or other side effects, you should immediately contact your eye care professional.


Ask your eye care professional if COMBIGAN® ophthalmic solution is right for you!

Back to Top

Will COMBIGAN® cure my type of glaucoma?

No. There is no cure for open-angle glaucoma. But high eye pressure is a risk factor that can be treated.

Back to Top

How do I use COMBIGAN®?

Take COMBIGAN® ophthalmic solution exactly as your eye care professional prescribed. The recommended dose is 1 drop of COMBIGAN® in the affected eye(s) twice daily approximately 12 hours apart. If more than 1 topical ophthalmic product is to be used, the different products should be instilled at least 5 minutes apart.7


If you wear contact lenses, remove them first, then wait 15 minutes after using COMBIGAN® ophthalmic solution before you put them back into your eyes.7

Back to Top

What are the side effects of COMBIGAN®?

The most common adverse reactions occurring in approximately 5% to 15% of patients (n = 385) included7:

  • Allergic inflammation of the eye
  • Abnormally large lymph follicles in the mucous membrane lining the inner surface of the eyelid and the exposed surface of the eyeball (also called the conjunctiva)
  • Eye redness
  • Severe itching of the eyes
  • Burning and stinging of the eyes

COMBIGAN® eyedrops can be absorbed by your body. Contact your eye care professional right away if you experience any of the following potential serious side effects:

  • Shortness of breath
  • Visual changes
  • Irregular heartbeat and/or slowing of your heart rate

COMBIGAN® ophthalmic solution may cause fatigue and/or drowsiness. If you drive or perform hazardous work, such as operating machinery, make sure you feel appropriately alert.


Ocular hypersensitivity reactions have been reported, with some reported to be associated with an increase in intraocular pressure.


These risks are not the only risks associated with COMBIGAN®. If you experience these or other side effects, you should immediately contact your eye care professional.

Back to Top

What can I do to manage my high eye pressure?

The best thing you can do to manage your high eye pressure is to follow your IOP-lowering therapy exactly as your eye care professional prescribed. You should talk to your doctor before you stop taking COMBIGAN® or any other eye pressure–lowering medication.

Back to Top

Indication: COMBIGAN® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is approved for reducing elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP. COMBIGAN® lowers IOP slightly less than taking both brimonidine tartrate three times a day and timolol maleate two times a day.

IMPORTANT SAFETY INFORMATION
Contraindications: COMBIGAN® ophthalmic solution should not be used by patients who have or ever had a reactive airway disease including bronchial asthma, chronic bronchitis, emphysema, slow heartbeat, impaired conduction of the heart, heart failure, or impaired pumping of the heart. COMBIGAN® should not be used in patients aged 2 years and younger, or by patients with hypersensitivity to any ingredient in this product.

See more below.