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Getting started

Remember to use COMBIGAN® twice a day, every day.

The recommended dose of COMBIGAN® is 1 drop in the affected eye(s) twice a day, about 12 hours apart.

COMBIGAN® may be used alone or with other eye drops to lower eye pressure for your glaucoma requiring additional IOP-lowering therapy.

If you use more than 1 type of topical eye drop, they should be applied at least 5 minutes apart.

IOP=intraocular pressure.

Instructions for applying eye drops

Step One Visual

Step 1

Wash your hands. Tilt your head back and look at the ceiling.

  • If you wear contact lenses, remove them first, then wait 15 minutes after using your eye drops to put them back into your eyes.
Step Two Visual

Step 2

Using your index finger, pull down your lower eyelid to form a pocket.

Step Three Visual

Step 3

Gently squeeze 1 drop into the pocket. Don’t let the bottle tip touch your eye, your fingers, or anything else.

Step Four Visual

Step 4

Gently close your eyes and lightly press on the inside corners of your eyes.

Step Five Visual

Step 5

Carefully blot away any excess liquid that may be on your skin.


COMBIGAN® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is used for the reduction of high eye pressure, also called intraocular pressure (IOP), in patients with glaucoma who require additional (or adjunctive) IOP-lowering therapy. COMBIGAN® lowers IOP slightly less than taking both brimonidine tartrate 3 times a day and timolol maleate 2 times a day.


Do not use COMBIGAN® 0.2%/0.5%:
  • If you have reactive airway disease, including bronchial asthma, a history of bronchial asthma, or severe chronic obstructive pulmonary disease (COPD)
  • If you have a very serious heart condition that causes a slowing of heart rate, such as sinus bradycardia (slow heart rate), second- or third-degree atrioventricular (AV) block, overt cardiac failure, or cardiogenic shock
  • In neonates and infants (under the age of 2 years)
  • If you are allergic or hypersensitive to any of the ingredients
  • COMBIGAN® 0.2%/0.5% contains timolol maleate, a beta-blocker. With use of beta-blockers, there is a potential for severe respiratory or cardiac reactions (a range of conditions affecting the lungs or heart). These severe reactions may include death due to bronchospasm in patients with asthma and in patients with a history of heart failure and/or mild or moderate chronic bronchitis, emphysema, or similar lung conditions.

COMBIGAN® 0.2%/0.5% should be used with caution in patients with:
  • Depression
  • Cerebral or coronary insufficiency (conditions that result in reduced blood supply to the brain or heart)
  • Raynaud’s phenomenon (a condition that results in reduced blood supply, most commonly, to the fingers and toes)
  • Orthostatic hypotension (a form of low blood pressure that occurs when standing after sitting or lying down)
  • Thromboangiitis obliterans (Buerger’s disease) (condition that results in reduced blood supply to the arms and legs, usually presenting in fingers and feet)
  • A propensity for or a history of: severe allergic reactions, including anaphylactic reactions to a variety of allergens
  • New or worsening muscle weakness and/or other symptoms of myasthenia gravis (eyelid droop, double vision, and generalized weakness)
  • Diabetes and spontaneous low blood sugar; the symptoms of sudden low blood sugar may be masked
  • Hyperthyroidism

Avoid allowing the tip of the dispensing bottle to touch the eye, anything around the eye, fingers, or any other surface to avoid contamination by common bacteria known to cause eye infections (bacterial keratitis). Using contaminated solutions can cause serious damage to the eye and loss of vision. Always replace the cap after using. Do not use after the expiration date marked on the bottle or if the solution changes color or becomes cloudy.

If you have eye surgery, eye trauma or infection, or develop any eye reactions, immediately consult with your physician about continuing the use of COMBIGAN® 0.2%/0.5%.

If you use more than one drug in the eye, be sure to wait at least 5 minutes between each drug application.

COMBIGAN® 0.2%/0.5% contains an ingredient that may be absorbed by and cause discoloration of soft contact lenses. If you wear contact lenses, remove them before using COMBIGAN® 0.2%/0.5%. Then wait 15 minutes after using COMBIGAN® 0.2%/0.5% before you put your contacts back into your eyes.

As with other similar medications, COMBIGAN® 0.2%/0.5% may cause fatigue and/or drowsiness in some patients. Patients who engage in hazardous activities should be aware of the potential for a decrease in mental alertness.

The most common side effects (5%-15%) in the clinical trial include allergic eye reaction, inflammation of the conjunctiva (“pink eye”), eye redness, itchy eye, eye burning, and stinging sensations. These are not all of the possible side effects with COMBIGAN® 0.2%/0.5%. Tell your doctor if you have any side effect that bothers you or that does not go away.

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